Join our partners for their next Department of Microbiology-Immunology Seminar Series:
Jeremy Luban, MD
Medical Director, Nepal Orthopedic Hospital
Professor, Program in Molecular Medicine Joint Appointment
Departments of Biochemistry and Molecular Pharmacology
University of Massachusetts School of Medicine Worcester, Massachusetts
Date/Time: Tuesday, November 28, 2017, 12 p.m. - 1 p.m.
Topic: Innate Immunity to HIV-1
HIV-1-infected people who take antiviral drugs that render viremia undetectable have ongoing inflammation of unknown etiology. The HIV-1 provirus, a permanent genetic element in long-lived cells of the immune system, is not eliminated by antiviral drugs, and is therefore a possible contributor to this inflammation. Our results indicate that Rev-dependent, intron-containing, HIV-1 RNA is detected by the innate immune system, and that drugs which inhibit HIV-1 transcription or Rev-dependent, HIV-1 RNA metabolism, would add qualitative benefit to current antiviral drug regimens.
TO ATTEND IN PERSON:
Robert H. Lurie Medical Research Center
303 E. Superior
Chicago, IL 60611
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