National and International Implementation Sustainment of Parent Management Training (PMTO) in Oregon
Marion Forgatch, PhD
Oregon Social Learning Center
Friday May 31st to Saturday June 1st 2019
With an NIH Pre-Conference Workshop on Thursday May 30th
At Emory University in Atlanta, GA.
Abstracts due: December 15th 2018
For more Information please visit the conference website: https://lgbtqconference.dryfta.com/en/
About the Conference
The National LGBTQ Health Conference is an interdisciplinary translational research conference bringing together scientists, public health professionals, and healthcare providers to discuss issues affecting the health and wellbeing of the LGBTQ community while fostering professional development and networking opportunities.
Nationally-recognized Keynote Speakers: Dr. Eliseo J. Pérez-Stable, Director of the National Institute on Minority Health and Health Disparities, National Institutes of Health, and Kierra Johnson, Deputy Executive Director of the National LGBTQ Task Force
Expert panel and breakout sessions showcasing emerging research and practice
Professional Development Institute hosted by NIH on May 30
Continuing education units will be offered
A paradigm shift is occurring in medicine and public health. Previously, trials were intended to identify the intervention with the greatest expected effect for a group of patients at risk for or diagnosed with a given disease or condition. As new and better interventions were identified this way, practice shifted towards the superior interventions. However, even if an intervention is best on average, some individuals may do better than expected while others may not do as well. Similarly, even if all individuals do about the same, some may have more serious adverse events/harms/unintended effects and others may have fewer. If differences in outcomes and harms with each intervention can be predicted for individuals, then the choice of intervention can be tailored and individualized – each person can get the intervention that most ideally achieves better health outcomes while minimizing harms for that person in particular. This is the new paradigm of individualized care, personalized medicine and health. Individualized care holds great promise, but achieving this promise presents a number of challenges. One particular challenge that we focus on is when to individualize care based on current knowledge (information from completed studies) and when and how to design additional studies that should be conducted before care is individualized. Currently most trials focus on showing effects for the group as a whole. After the trial concludes, additional analyses attempt to predict which subgroups will benefit more from which treatment. Even when these analyses find differences, they may be highly uncertain because the original trial was not made large enough to precisely measure these differences at these subgroup levels. The subgroup findings are suggestive, and it may be tempting to individualize treatment based on them. Yet, because treatments carry both the promise of benefits and risks of harms and side-effects, additional studies may be warranted. But when? And how large of a study? And on which subgroups should the new study focus on? Towards answering these questions, we describe a framework we developed. We then apply this framework using simulation model examples to characterize what are the characteristics of the subgroups and their expected benefits, risks and associated uncertainties as well as the maximum available sample size that determines optimal study designs for individualization decisions. In many cases, we consider optimal study designs diverge strongly (but predictably) from proportional random sampling schemes like those currently used in many randomized trials.
Monday November 12, 2018
12PM to 1PM CDT
Drs. Joshua Leonard and Chisu Song will present the results of their Third Coast CFAR pilot projects.
Joshua L. Leonard, PhD is an associate professor of chemical and biological engineering at Northwestern University McCormick School of Engineering. His research group works at the interface of systems biology and synthetic biology in order to probe and program the function of complex, multicellular systems to develop transformative biotechnologies and enable a new paradigm of design-driven medicine. Using the tools of synthetic biology, biomolecular engineering, computational systems biology, and gene therapy, they develop technologies including programmable cell-based “devices,” immune therapies for cancer and chronic disease, smart vaccines, biosensors for global health applications, and tools for advanced metabolic engineering. By bringing an engineering approach to the investigation, design, and construction of biological systems, Dr. Leonard’s research group is advancing the frontiers of design-driven medicine to address unmet medical needs and create safe, effective, and long-lasting treatment options that improve both quantity and quality of life.
Chisu Song, PhD is a research assistant professor of medicine in the Division of Infectious Diseases at Northwestern University. Dr. Song received his doctorate in Virology at the University of Alabama-Birmingham in 2001. He completed his postdoctoral training in Microbiology and Hematology-Oncology at the University of Alabama and Microbiology and Immunology at Vanderbilt University. Dr. Song's work includes studying APOBEC3G to identify potential strategies for sustained remission in individuals with HIV.
JD and Nanette will present results from a scoping review of NIH-funded grants which will identify the proportion and characteristics of HIV-related implementation research studies funded by NIH, discuss multiple implementation research methods used to study interventions targeting various points in the HIV prevention and care continuums, and present potential opportunities for next steps.
Join the Third Coast Center for AIDS Research 2018 Annual Symposium Ending the HIV Epidemic: Think Globally, Act Locally. This multidisciplinary symposium will draw important connections between HIV research in global settings and the lessons researchers can apply to their domestic work. Examples of the “global to local” approach will include innovations in HIV testing, prevention and care, as well as implementation science approaches to scale up of new interventions, and the role of research on non-communicable diseases and HIV.
Ambassador Deborah L. Birx, United States Global AIDS Coordinator will provide a keynote lecture on the scale up of HIV treatment through the President’s Emergency Plan for AIDS Relief (PEPFAR) programs.
Ce-PIM Director, Dr. C Hendricks Brown, will join Dr. Carlos Del Rio (Emory) and Dr. Moira McNulty (Univ of Chicago) as a presenter in Session III: Implementation Science to Accelerate the Cascades.
For more more information on this symposium, including the agenda, please visit: http://www.thirdcoastcfar.org/annual-symposium/
Precision medicine is a concept that was nearly unheard of prior to 2008, but in 2018, PubMed listed nearly 4000 citations for the term “precision medicine.” The National Institutes of Health launched an ambitious precision medicine initiative in 2015 and began recruiting participants into a 1 million person cohort study in 2017. To date, nearly 100,000 people have joined this effort, now called the “All of Us Research Program.” As described by the NIH, All of Us is “more than just a medical research program.” It is described as “a celebration of the American spirit in all its diversity and capacity to generate positive change.” The goal of the cohort study is to create a health care environment that is based on specific treatments for specific individuals. It takes into account factors like where a person lives, what activities they do, and what is their family health history. Precision medicine’s goal is to be able to tell people the best ways to stay healthy. If someone does become ill, precision medicine may help health care teams find the treatment that will work best. The study expects to provide researchers, patients, and doctors the information they need to make tailored recommendations, relevant to people of different backgrounds, ages, or regions.In this talk, Drs. Ho and Greenland will discuss the overall program goals as well as the evolving data elements and genomic analysis plan, and the researcher portal, which will enable researchers from anywhere to utilize data from the study. We will also discuss related projects, like the UK Biobank and the Million Veterans Study, to learn from those experiences and anticipate what we may learn from the All of Us Research Program.
Keywords: precision medicine; personalized medicine; genetics; health risks
Communities That Care (CTC) is a community planning system for the prevention of youth behavior problems. CTC empowers community stakeholders and decision makers to select and implement tested and effective policies and programs most appropriate to their community’s needs by using strategic consultation, training, and research-based tools. We see CTC as providing what NIRN calls the “enabling context” for successful implementation of prevention focused EBPs. This session will briefly summarize findings from the NIH/NIDA-funded community-randomized trial of CTC and describe efforts to expand capacity for implementation at scale using a new web-based video-assisted training system. The CTC prevention system has been shown to assist local communities in achieving these goals in a randomized trial. We will discuss how we have continued to focus on high quality implementation from the randomized trial to real world application of CTC.
Monday October 22nd, 2018
12PM to 1PM CDT
Dr. Currier is Professor of Medicine and Chief of the Division of Infectious Diseases and Co-Director of the Center for AIDS Research and Education Center (CARE) in the Department of Medicine at University of California, Los Angeles (UCLA). She is Chair of the NIH sponsored AIDS Clinical Trials Group. Her research has focused on HIV therapeutics and long-term complications of HIV disease with an emphasis on sex differences and antiretroviral therapy, cardiovascular disease, and women’s health.
Randomized trials provide the gold standard of internal validity for making causal inferences about the effects of interventions. However, randomized trials are seldom conducted using probability samples that might provide the same gold standard of generalizability (external validity). I will discuss methods to quantify and improve the generalizability of findings from randomized trials conducted to inform policy and illustrate these ideas with the FIRST trial. I will begin by formalizing some subjective notions of generalizability in terms of estimating average treatment effects in well-defined inference populations. The problem is to use a study sample to estimate parameters of the distribution of treatment effects (e.g., the average treatment effect) in an inference population. When study samples are not probability samples, the inference process relies on matching the study sample to the inference population on a potentially large number of covariates that are related to variation in treatment effects. I outline methods that can, under definable assumptions, yield estimates of the population average treatment effects are unbiased (or nearly so) with a standard error depends largely on how well the study sample matches the inference population. If the standard error is reasonably small, the study sample yields generalizable effects, but if it is large (or even infinite, as it can be) the evidence in the study sample has little or no generalizability to the inference population. I use the Flexibility In duty hour Requirements for Surgical Trainees (FIRST) trial to illustrate the use of these ideas.
This lecture will be on Thursday, October 11th 2018 in the Stonewall Conference Room of 625 N. Michigan Suite 1400. Stay tuned for more details!
Implementation strategies and many of the clinical and health service delivery interventions they aim to implement are characterized by multiple components targeting multiple behaviors and levels and are often characterized by extreme heterogeneity and adaptability. Although researchers often attempt to standardize and achieve fidelity to highly-specified manualized intervention protocols, the required actions to suppress adaptation and maximize internal validity often lead to reduced effectiveness: adaptation to local conditions often increases intervention effectiveness relative to implementation of a fixed version of an intervention across heterogeneous settings. This presentation introduces the new PCORI Methodology Committee Standards for Complex Interventions and discusses their role in research to (a) study and guide rather than suppress or ignore adaptation, achieving internal validity through adherence to an adaptation algorithm and through fidelity to function rather than form, and to (b) develop empirical evidence, insights and guidance for policy and practice decision makers who are charged with adapting and managing complex interventions rather than simply selecting and deploying simple, fixed interventions.
In my presentation I will briefly summarize the scope and rationale of agent-based modelling. Then, after listing the main challenges of the agent-based approach, I will focus on how to make make agent-based more transparent and rigorous. I will introduce to ODD, a standard format for describing ABMs, TRACE, a standard format for documenting the evaluation and validation of ABMs, and Robustness Analysis, a generic strategy for identifying robust theories.
The presentation will provide an overview of effectiveness-implementation hybrid designs. Dr. Curran will review current trends in the use of these designs, provide examples of strong designs across the hybrid design continuum, and offer recommendations for hybrid design specifications, outcome measurement, and reporting.
Keywords: research design, implementation science, hybrid designs
George J. Greene, Ph.D., (he/him) is the associate director of the Evaluation, Data Integration, and Technical Assistance Program (EDIT) and faculty in the Department of Medical Social Sciences at Northwestern University. Dr. Greene’s research interests focus on health disparities in lesbian, gay, bisexual, and transgender (LGBT) adolescents and young adults, with a particular emphasis on ethnic/racial disparities in the HIV epidemic. His research aims to: (a) understand HIV risk and protective factors from intersectionality and developmental-ecological perspectives; (b) employ community-based participatory research approaches to build upon the needs and strengths of communities to identify and develop effective interventions; (c) design technology- and Internet-based approaches for observation and intervention; (d) adopt theoretically-driven program evaluation approaches to appropriately evaluate HIV prevention research and service efforts; and (e) apply qualitative and mixed methods approaches to research and program evaluation efforts
Guidelines to submit abstracts can be found here: http://www.thirdcoastcfar.org/abstract-guidelines/
Register to attend the symposium by October 26th.
Ce-PIM Director, Dr. C Hendricks Brown, will join Dr. Carlos Del Rio (Emory) and Dr. Moira McNulty (Univ of Chicago) as a presenter in Session III: Implementation Science to Accelerate the Cascades.
Information on how to register and the symposium agenda can be found here: http://www.thirdcoastcfar.org/annual-symposium/
The 2018 Midwest LGBTQ Health Symposium (MLHS) will explore this year’s theme “Moving Towards Health Equity. Strengthening our Community of Care.” The two-day gathering of healthcare professionals, social service providers, advocates, and researchers will highlight innovative best practices in LGBTQ patient-centered clinical care as well as community-driven approaches to addressing health disparities. Join us as we explore these critical topics and others - HIV elimination, racial equity in LGBTQ care, addressing violence and reproductive justice, as providers and advocates striving for meaningful change.
Please visit the conference website for more information on how to register and to view this year's schedule.
Ce-PIM faculty, Hendricks Brown, JD Smith, and Nanette Benbow will be attending an all day meeting of the HIV Implementation Science Working Group at Johns Hopkins School of Public Health.
ISGMH's third annual symposium focuses on the intersection between racial and ethnic minorities and sexual and gender minority populations. Research and community experience show that these populations experience numerous discrimination, oppression and health disparities. Those who identify as a sexual or gender minority, and as a person of color, can experience these disparities in compounding ways. For example, transgender women of color and black gay men are at high risk for poor health outcomes, and there is a staggering disparity between their health outcomes and that of their heterosexual, cisgender and white peers. The objective of this Symposium is to identify areas where research can directly improve the health and wellbeing of ethnic, racial, sexual and gender minorities.
The Keynote Speaker at this year’s Symposium is Dr. Lisa Bowleg, a professor of applied social psychology and the director of DC CFAR Social and Behavioral Sciences Core at The George Washington University. The Symposium will also feature speakers representing an interdisciplinary mix of Northwestern University faculty, postdoctoral and graduate students showcasing their research, as well as local community organizers.
Join our partners, ISGMH, for their “Current Issues in LGBTQ Health” lecture series featuring André Pérez! André will be discussing his work with the Trans Oral History project and America in Transition
This lecture will be on Tuesday, August 7th, 2018 from 12:00-1:30 in the Stonewall Conference Room of 625 N. Michigan Suite 1400. Stay tuned for more details!
On August 3rd, Dr. Hendricks Brown will give a presentation at the Center for Latino Health Research Opportunities (CLaRO) Summer Training Institute. This interdisciplinary Center conducts and promots multi-level community-based participatory research to prevent SAVA syndemic conditions (substance abuse, violence/trauma and HIV/AIDS) and reduce their adverse health and mental health consequences. The Center emphasizes tailored interventions for Latino subgroups who represent pockets of vulnerability and require precise and specialized interventions that optimize access to and impact of interventions. From Friday, July 27th to Sunday, August 5th, the CLaRO Summer Training Institute will be held at the University of Miami.
Friday, July 27, 2018: 8:30am- 3:00pm
Saturday, July 28, 2018: 8:30am- 12:00pm
Sunday, July 29, 2018: 8:30am- 12:00pm
Monday, July 30, 2018: 8:30am- 3:00pm
Tuesday, July 31, 2018: 8:30am- 3:00pm
Wednesday, August 1, 2018: 8:30am- 3:00pm
Thursday, August 2, 2018: 8:30am- 3:00pm
Friday, August 3, 2018: 8:30am- 12:00pm
Saturday, August 4, 2018: 8:30am- 11:30am
Sunday, August 5, 2018: 8:30am- 11:30am
The National Institute on Minority Health and Health Disparities (NIMHD) will host the Health Disparities Research Institute (HDRI) from July 23 - 27, 2018. The HDRI aims to support the research career development of promising minority health/health disparities research scientists early in their careers and stimulate research in the disciplines supported by health disparities science.
For more information, please visit https://www.nimhd.nih.gov/programs/edu-training/hd-research-institute/hdri_logon.asp
Join our partners, ISGMH, for their “Current Issues in LGBTQ Health” lecture series featuring Dr. Brian Hitsman!
This lecture will be on Wednesday, July 11th 2018 from 12:00-1:30 pm in the Stonewall Conference Room of 625 N. Michigan Suite 1400. Stay tuned for more details!
The University of Pennsylvania’s Perelman School of Medicine will be hosting the 2018 Implementation Science Institute June 19-21, 2018. The purpose of the Implementation Science Institute is to provide participants with the tools to design and execute rigorous implementation science research. The Institute will give an introduction to the foundations of implementation science (i.e., terminology, conceptual models and frameworks, study design). Students will also receive an overview of advanced topics including implementation strategies and sustainability. The course directors will cover tips for grant writing, skill development and time will be spent writing specific aims for Implementation Science grants. The Institute will also explicitly describe how principles of implementation science can be applied to practical implementation efforts.
For more information and to register, please visit http://news.consortiumforis.org/training/2018-implementation-science-institute-at-university-of-pennsylvania/
The Office of Behavioral and Social Sciences Research (OBSSR) in coordination with a number of National Institutes of Health (NIH) Institutes and Centers and the U.S. Department of Veterans Affairs (VA), are hosting this training institute to provide participants with a thorough grounding in conducting D&I research in health across all areas of health and health care.
In 2018, the institute will utilize a combination of a 4-month online course (six modules with related assignments) between August 13 and November 30 , 2018, and a 2-day in-person training to be held December 6-7, 2018, in Bethesda, MD. Faculty and guest lecturers will consist of leading experts in theory, implementation, and evaluation approaches to D&I; creating partnerships and multilevel, transdisciplinary research teams; research design, methods, and analyses appropriate for D&I; and conducting research at different and multiple levels of intervention (e.g., clinical, community, policy).
Participants will be expected to return to their home institutions prepared to share what they have learned at the institute to help further the field of D&I research (e.g., giving talks, leading seminars, forming new collaborations, mentoring, submitting D&I grant proposals, etc.).
Join our partners, ISGMH, for their “Current Issues in LGBTQ Health” lecture series featuring Dr. Héctor Carrillo!
This lecture will be on Thursday, June 7th 2018 from 12:00-1:30 pm in the Stonewall Conference Room of 625 N. Michigan Suite 1400. Stay tuned for more details.
Keynote Speaker: Tyler VanderWeele, Harvard School of Public Health: “Assessing Mediation, Interaction, and Causation in the Associations Between Religious Service Attendance and Suicide”
Discussant: Naihua Duan, Columbia University
Hendricks Brown, Northwestern University Feinberg School of Medicine: “Designing implementation trials for scaling up and scaling out evidence based interventions”
Discussant: Larry Hedges, Northwestern University
Sherri Rose, Harvard Medical School: “Computational Health Economics and Clinical Informatics in Mental Health Research"
Discussant: Neil Jordan, Northwestern University
Danny Almirall, University of Michigan: "Mixed-effects Modeling to Compare Dynamic Treatment Regimens with SMART Data"
Discussant: Yuanjia Wang, Columbia University
Susan Paddock, Rand Corporation: “Causal inference for dynamic groups: Examining cognitive behavioral therapy session attendance and post-treatment depression”
Discussant: Steve Raudenbush, University of Chicago
Haiqun Lin, Yale University: “Multiple Mediation Analysis with Latent Classes”
Discussant: Robert Gibbons, University of Chicago
Mengling Liu, NYU: "Mediation Analysis with Censored Time-to-Event Mediator"
Discussant: Bethany Bray, Penn State University
Melanie Wall, Columbia University: “Empirical methods for identifying optimal diagnostic criteria for psychiatric disorders"
Discussant: Christine Mauro, Columbia University
Ian Barnett, University of Pennsylvania: “Multivariate change point detection methods with applications to relapse prediction in schizophrenia using smartphone monitoring”
Discussant: Eva Petkova, NYU
There will be a total of eight 35-minute regular invited talks each with a 15-minute discussion. The Keynote Address is 50 minutes with a 20-minute discussion.
9:30am-10:00am: Registration and coffee
10:10am-11:00am: Danny Almirall (Speaker) & Yuanjia Wang (Discussant)
11:00am-11:50am: Susan Paddock (Speaker) & Steve Raudenbush (Discussant)
11:50am-1:00pm: Lunch Onsite
1:00pm-1:50pm: Haiqun Lin (Speaker) & Robert Gibbons (Discussant)
1:50pm-2:40pm: Ian Barnett (Speaker) & Eva Petkova (Discussant)
2:40pm-3:00pm: Afternoon Coffee/Snack Break
3:00pm-4:10pm: Tyler VanderWeele (Keynote Speaker) & Naihua Duan (Discussant)
4:10pm-4:20pm: General Discussion
4:20pm-6:20pm: Happy Hour and poster session
6:30pm-8:00pm: Dinner at Beatrix (not included in registration fee)
8:30am-9:00am: Continental breakfast onsite
9:00am-9:50am: Hendricks Brown (Speaker) & Larry Hedges (Discussant)
9:50am-10:40am: Sherri Rose (Speaker) & Neil Jordan (Discussant)
10:40am-11:00am: Mid-morning coffee/snack break
11:00am-11:50am: Melanie Wall (Speaker) & Christine Mauro (Discussant)
11:50am-12:40pm: Mengling Liu (Speaker) & Bethany Bray (Discussant)