Nov
28
12:00 PM12:00

PSMG: Personalized Medicine Series - Daniel Almirall, presenting on "Getting SMART about adaptive interventions in treatment, prevention and implementation science"

Getting SMART about adaptive interventions in treatment, prevention and implementation science

Daniel Almirall, Ph.D.
University of Michigan

ABSTRACT:
The effective treatment, prevention or management of a wide variety of health disorders often requires individualized, sequential decision-making. To do this, each individual’s intervention is tailored over time based on the individual’s history, e.g., changing disease or risk status, or adherence. Adaptive interventions (also known as dynamic treatment regimens in the statistical medicine literature) operationalize such individualized decision making using a sequence of decision rules that pre-specify which intervention option to offer, for whom, and when. Intervention options in this case correspond to varying doses, types or delivery modes of pharmacological, behavioral and/or psychosocial interventions. Recently, there has been a surge of interest in developing and evaluating adaptive interventions via randomized trials. Specifically, there is great interest in the use of sequential multiple assignment randomized trials (SMART), a type of multi-stage randomized trial design, to build high-quality adaptive interventions. The primary aim of this talk is to provide a brief, conceptual introduction to adaptive interventions and SMART designs. We will use various examples of adaptive interventions and SMART studies in child and adolescent mental health (e.g., ADHD, autism) to explain and illustrate ideas. If time permits, a secondary aim of this talk is to introduce the idea of adaptive implementation interventions and the use of cluster-randomized SMART designs for their development. In an adaptive implementation intervention, the intervention options—which, typically, are strategies designed to improve the uptake or delivery of evidence-based practices by a provider/site—are tailored over time based on the changing status of the provider/site. As an illustrative example, we will present the design of the AIM-Hi Study, a NIMH-funded cluster-randomized SMART which aims to develop a high-quality adaptive implementation intervention to improve the uptake/adoption of cognitive behavioral treatment in high-schools.

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Nov
28
3:00 PM15:00

Workshop: Implementation Science 201

Implementation Science 201:
Overview of experimental designs for implementation research with applications to HIV

Hendricks Brown, Ph.D.
J.D. Smith, Ph.D.

Register Via Eventbrite: http://bit.ly/2zs575n

Attend in Person:
Stonewall Conference Rooms, Suite 1400
625 N. Michigan Avenue, Chicago, IL

Attend in Person via VideoLink:
Wyler Pavillion, Room L-316
University of Chicago Medical Center
5837 S. Maryland Avenue, Chicago, IL

View via BlueJeans:
App: Meeting ID = 274088775
Browser: https://bluejeans.com/274088775/browser
Phone: +1-408-740-7256 or +1-888-240-2560 (US Toll Free)

IS201Flyer.jpg
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Dec
7
12:00 PM12:00

ISGMH Lecture: Current Issues in LGBTQ Health featuring Dr. Kirsten Simonton presenting “LGBTQ Youth in Foster Care: Coming Out of the Margins”

We invite you to join our collaborative partners for their next Current Issues in LGBTQ Health lecture featuring Kirsten Simonton, MD

This lecture will be on Thursday, December 7th from 12:00-1:30 pm in the Stonewall Conference Room of 625 N. Michigan Suite 1400. This lecture is being co-sponsored by The Sexualities Project at Northwestern (SPAN).

********TO REGISTER, PLEASE VISIT ISGMH'S EVENT PAGE *************

Abstract: Lesbian, gay, bisexual, transgender and questioning (LGBTQ) youth are reported to be overrepresented in the foster care system, which studies suggest may be related to increased rates of family rejection or disapproval.  Rejection related to sexual or gender identity, as well as involvement in child welfare, places these youth at greater risk for many negative outcomes including mental health challenges, substance abuse, lower rates of family permanency, and higher likelihood of multiple foster placements and homelessness.  Understanding the physical and mental health risks in this population is critical for providers to inform best practices in the medical and child welfare settings.  Emerging child welfare practices are emphasizing early identification, safety in the foster care setting, and a focus on permanency.  Ongoing work is needed to ensure appropriate medical and mental health care, elimination of discriminatory practices, and supports for families of origin to move toward acceptance.

Dr. Simonton (pronouns: she/her/hers) joined the Child Abuse Division faculty at Lurie Children’s Hospital in December 2016, and is an Assistant Professor of Pediatrics at Northwestern Feinberg School of Medicine.  She completed residency training in pediatrics at Carolinas Medical Center in Charlotte, NC in 2012, and remained there as Chief Pediatric Resident during the 2012-2013 academic year.  She then completed fellowship training in Child Abuse Pediatrics at Cincinnati Children’s Hospital Medical Center, where she developed a particular interest in the health of children in foster care.  She has led clinical research and quality improvement projects in the Foster Care Clinic at Cincinnati Children’s Hospital with specific focus on the LGBTQ population.  She has obtained grant support from the American Academy of Pediatrics to support her clinical initiatives, and has presented her work at national academic meetings.  In fellowship, she was involved in a collaboration led by the US Department of Housing and Urban Development to end LGBTQ youth homelessness in greater Cincinnati.  She has particular interests in process improvement, and interventions designed to improve the lives of children who have experienced trauma or marginalization.

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Dec
12
12:00 PM12:00

PSMG: HIV Series - Cyprian Wejnert presenting on "CDC's National HIV Behavioral Surveillance (NHBS) system"

CDC's National HIV Behavioral Surveillance (NHBS) system: Methods and impact on HIV prevention among key populations

Cyprian Wejnert, Ph.D.
Centers for Disease Control and Prevention

ABSTRACT:
The National HIV Behavioral Surveillance (NHBS) system was designed to monitor risk factors for HIV infection and HIV prevalence among individuals at increased risk for HIV infection, that is, sexually active men who have sex with men who attend venues, persons who recently injected drugs, and heterosexuals of low socioeconomic status living in urban areas. These groups were selected as priorities for behavioral surveillance because they represent the major HIV transmission routes and the populations with the highest HIV burden. Accurate data on HIV risk and testing behaviors in these populations are critical for understanding trends in HIV infections and planning and evaluating effective HIV prevention activities. This presentation will provide an overview of NHBS and the methods it employs (respondent-driven sampling and venue-based sampling), and will highlight some of the impact findings from NHBS have had on HIV prevention.

 

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Dec
13
11:00 AM11:00

Northwestern Psych Dept. Grand Rounds: Inger Burnett-Zeigler, PhD, presenting on Racial/Ethnic Disparities in Mental Health Service

  • Prentice Women’s Hospital, Canning Auditorium (map)
  • Google Calendar ICS

Topic: Complementary and Integrative Approaches to Reducing Racial/Ethnic Disparities in Mental Health Service Utilization

Presenter: 
Dr. Inger Burnett-Zeigler
Assistant Professor Department of Psychiatry and Behavioral Sciences
Feinberg School of Medicine
Northwestern University

Host: Katherine Wisner, MD

Location:
Prentice Women’s Hospital
Canning Auditorium
250 East Superior Street, 3rd Floor
Chicago, Illinois 6061

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Jan
10
5:00 PM17:00

Third Coast CFAR Pilot Funds: Letter of intent survey due

PILOT FUNDS AVAILABLE for HIV/AIDS RESEARCH

The Third Coast Center for AIDS Research (CFAR) is pleased to announce a Request for Applications for pilot awards for HIV/AIDS research.

Third Coast CFAR Faculty Members are eligible to serve as the Principal Investigator (PI) on these grants.  Affiliate Members are eligible to serve as co-PIs and collaborators.  The PI must be a new investigator (never PI on R01-equivalent NIH grant) or an established investigator that has never received R01-equivalent NIH funding for HIV/AIDS research.

Required Third Coast CFAR membership is free and it is easy to sign-up here.

Pilot awards are intended for key preliminary studies in HIV-related basic, clinical, or behavioral research that will enable new NIH grant submissions and stimulate cross-institutional and/or cross-disciplinary collaborations.

Maximum project direct costs: $50,000
Required letter of intent survey due: January 10, 2018 - Submit here.
Mandatory pre-submission review meeting: January 22, 2018
Applications due: February 28, 2018
Awards announcement expected: late April 2018
Project start date:  Varies depending on regulatory and administrative components required.

Full RFA, with eligibility and application instructions, is available here.

Questions?  Contact Fern Murdoch at f-murdoch@northwestern.edu

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Jan
22
5:00 PM17:00

Third Coast CFAR Pilot Funds: Pre-submission review meeting

PILOT FUNDS AVAILABLE for HIV/AIDS RESEARCH

The Third Coast Center for AIDS Research (CFAR) is pleased to announce a Request for Applications for pilot awards for HIV/AIDS research.

Third Coast CFAR Faculty Members are eligible to serve as the Principal Investigator (PI) on these grants.  Affiliate Members are eligible to serve as co-PIs and collaborators.  The PI must be a new investigator (never PI on R01-equivalent NIH grant) or an established investigator that has never received R01-equivalent NIH funding for HIV/AIDS research.

Required Third Coast CFAR membership is free and it is easy to sign-up here.

Pilot awards are intended for key preliminary studies in HIV-related basic, clinical, or behavioral research that will enable new NIH grant submissions and stimulate cross-institutional and/or cross-disciplinary collaborations.

Maximum project direct costs: $50,000
Required letter of intent survey due: January 10, 2018 - Submit here.
Mandatory pre-submission review meeting: January 22, 2018
Applications due: February 28, 2018
Awards announcement expected: late April 2018
Project start date:  Varies depending on regulatory and administrative components required.

Full RFA, with eligibility and application instructions, is available here.

Questions?  Contact Fern Murdoch at f-murdoch@northwestern.edu

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Jan
23
12:00 PM12:00

PSMG: Implementation Methods Series - Shri Narayanan

Deriving multimodal behavioral informatics for health applications

Shri Narayanan, Ph.D.
University of Southern California

ABSTRACT:
The convergence of sensing, communication and computing technologies is allowing capture and access to data, in diverse forms and modalities, in ways that were unimaginable even a few years ago.  These include data that afford the analysis and interpretation of multimodal cues of verbal and non-verbal human behavior to facilitate human behavioral research and its translational applications in healthcare.  These data not only carry crucial information about a person’s intent, identity and trait but also underlying attitudes, emotions and other mental state constructs. Automatically capturing these cues, although vastly challenging, offers the promise of not just efficient data processing but in creating tools for discovery that enable hitherto unimagined scientific insights, and means for supporting diagnostics and interventions. Recent computational approaches that have leveraged judicious use of both data and knowledge have yielded significant advances in this regard, for example in deriving rich, context-aware information from multimodal signal sources including human speech, language, and videos of behavior. These are even complemented and integrated with data about human brain and body physiology.   This talk will focus on some of the advances and challenges in gathering such data and creating algorithms for machine processing of such cues.  It will highlight some of our ongoing efforts in Behavioral Signal Processing (BSP)—technology and algorithms for quantitatively and objectively understanding typical, atypical and distressed human behavior—with a specific focus on communicative, affective and social behavior. The talk will illustrate Behavioral Informatics applications of these techniques that contribute to quantifying higher-level, often subjectively described, human behavior in a domain-sensitive fashion. Examples will be drawn from mental health and well being realms such as Autism Spectrum Disorders, Couple therapy, Depression and Addiction counseling. 

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Feb
28
5:00 PM17:00

Third Coast CFAR Pilot Funds: Application Due

PILOT FUNDS AVAILABLE for HIV/AIDS RESEARCH

The Third Coast Center for AIDS Research (CFAR) is pleased to announce a Request for Applications for pilot awards for HIV/AIDS research.

Third Coast CFAR Faculty Members are eligible to serve as the Principal Investigator (PI) on these grants.  Affiliate Members are eligible to serve as co-PIs and collaborators.  The PI must be a new investigator (never PI on R01-equivalent NIH grant) or an established investigator that has never received R01-equivalent NIH funding for HIV/AIDS research.

Required Third Coast CFAR membership is free and it is easy to sign-up here.

Pilot awards are intended for key preliminary studies in HIV-related basic, clinical, or behavioral research that will enable new NIH grant submissions and stimulate cross-institutional and/or cross-disciplinary collaborations.

Maximum project direct costs: $50,000
Required letter of intent survey due: January 10, 2018 - Submit here.
Mandatory pre-submission review meeting: January 22, 2018
Applications due: February 28, 2018
Awards announcement expected: late April 2018
Project start date:  Varies depending on regulatory and administrative components required.

Full RFA, with eligibility and application instructions, is available here.

Questions?  Contact Fern Murdoch at f-murdoch@northwestern.edu

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Apr
6
3:30 PM15:30

ISGMH Lecture: Current Issues in LGBTQ Health featuring Dr. Carlos Gallo

We invite you to join our collaborative partners, ISGMH, for their “Current Issues in LGBTQ Health” lecture series featuring Dr. Carlos Gallo of Ce-PIM.

ISGMH is cosponsoring this event with the Northwestern Department of Linguistics.

This lecture will be on Friday, April 6th 2018 from 3:30-5:30 pm on Northwestern’s Evanston campus. Stay tuned for more details!

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Nov
13
12:00 PM12:00

Third Coast CFAR Seminar: Nanette Benbow presenting on "Informing Public Health Action with Molecular HIV Surveillance in Illinois"

TC-CFAR Speaker Series


Informing Public Health Action with Molecular HIV Surveillance in Illinois

Nanette Benbow, M.A.S.

Stonewall Conference Rooms, Suite 1400
625 N. Michigan Ave, Chicago, IL

Nanette Benbow, M.A.S, (she/her) is a research assistant professor in the Department of Psychiatry and Behavioral Sciences at the Northwestern University Feinberg School of Medicine; Director of the Third Coast Center for AIDS Research (TC-CFAR) End HIV Scientific Working Group; and member of the Center for Prevention Implementation Methodology. Her research interests include the use of epidemiologic and network modeling to improve HIV prevention and care continua; health equity for Latinos and sexual and gender minorities; and developing academic-public health partnerships in implementing evidence-based interventions that reduce HIV incidence in local settings. 

Before joining the Northwestern Faculty in 2016, Ms. Benbow was deputy commissioner of the STI/HIV Services Bureau of the Chicago Department of Public Health (CDPH) where she oversaw the development and implementation of prevention and care interventions.

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Nov
7
12:00 PM12:00

Kathryn Risher: Challenges in the evaluation of interventions to improve engagement along the HIV care continuum in the United States

Challenges in the evaluation of interventions to improve engagement along the HIV care continuum in the United States

Kathryn Risher, Ph.D, M.H.S
London School of Hygiene & Tropical Medicine

ABSTRACT:
In the United States (US), a high proportion of individuals living with HIV remain unlinked to care, disengaged from care, or incompletely adherent to antiretroviral therapy (ART). We conducted a systematic review of interventions to improve linkage to care, retention in care, re-engagement among those disengaged from care, and adherence to ART in the US. We find that the bulk of evidence (117/152 included studies) addresses adherence interventions, while a very small minority address linkage or reengagement interventions (7/152 and 4/152, respectively). There was tremendous heterogeneity in measures used to evaluate interventions. We found that most (59%) of studies report significantly improved outcomes, but the effect size was variable across studies and populations. The presentation will additionally include recommendations to address the challenges identified by the systematic review.

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Oct
31
12:00 PM12:00

Sean Young: Social media for changing and predicting HIV

Social media for changing and predicting HIV

Sean Young, Ph.D.
University of California Los Angeles

ABSTRACT:
This talk will focus on how social media can be used in HIV prevention research. We'll discuss a social media-based online community for HIV prevention and ways that social media data can be used by HIV researchers.

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Oct
24
12:00 PM12:00

Emine Yaylali: Resource allocation models for HIV prevention

Resource allocation models for HIV prevention

Emine Yaylali, Ph.D.
Istanbul Technical University

ABSTRACT:
Objective: 

We will briefly explain resource allocation models, how these models could be used in improving HIV prevention and present some examples from literature. Then, we will describe HIV-RAMP, a resource allocation model to optimize health departments’ Centers for Disease Control and Prevention (CDC)–funded HIV prevention budgets to prevent the most new cases of HIV and to evaluate the model’s implementation in four health departments
Design, Settings, and Participants: 
We developed a linear programming model combined with a Bernoulli process model that allocated a fixed budget among HIV prevention interventions and risk subpopulations to maximize the number of new infections prevented. The model, which required epidemiologic, behavioral, budgetary, and programmatic data, was implemented in health departments in Philadelphia, Chicago, Alabama, and Nebraska. 
Main Outcome Measures: 
The optimal allocation of funds, the site-specific cost per case of HIV prevented rankings by intervention, and the expected number of HIV cases prevented.  
Results: 
The model suggested allocating funds to HIV testing and continuum-of-care interventions in all 4 health departments. Behavioral interventions did not receive funding in the optimal allocation for any health department. The most cost-effective intervention for all sites was HIV testing for men who have sex with men (MSM) in non-clinical settings, and the least cost-effective interventions were behavioral interventions for HIV-negative persons. The pilot sites required 3-4 months of technical assistance to develop data inputs and generate and interpret the results. Although the sites found the model easy to use in providing quantitative evidence on allocating HIV prevention resources, they criticized the exclusion of structural interventions and the use of model to allocate only CDC funds.   
Conclusions: 
Resource allocation models have potential to improve the allocation of limited HIV prevention sources and can be used as a decision-making guide for state and local health departments. Using such models may require substantial staff time and technical assistance. Model results suggesting allocating funds towards testing and continuum-of-care interventions and risk populations at highest risk of HIV transmission may lead to better health outcomes. These model results emphasize the allocation of CDC funds toward testing and continuum--of-care interventions and populations at highest risk of HIV transmission. 

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Oct
23
12:00 PM12:00

TC-CFAR Seminar: Dr. Robert Garofalo

Dr. Robert Garofalo will be presenting for the Third Coast CFAR Seminar Series

Dr. Garofalo’s primary clinical and research activities relate to the care of marginalized youth populations including HIV+ and LGBT young people. Research is largely HIV prevention in nature, mostly targeting either young men who have sex with men or transgender individuals. A new area of research and clinical interest involves working with young gender variant children and families.

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Oct
17
12:00 PM12:00

Cathy Maulsby & David Holtgrave: Economic analysis of AIDS United's access to Care Initiative

Economic analysis of AIDS United's access to Care Initiative

Cathy Maulsby, Ph.D. & David Holtgrave, Ph.D.
Johns Hopkins University

ABSTRACT:
Persons diagnosed with HIV but not retained in HIV medical care accounted for the majority of HIV transmissions in 2009 in the United States (U.S.). There is an urgent need to implement and disseminate HIV retention in care programs; however little is known about the costs associated with implementing retention in care programs. We assessed the costs and cost-utility for six Retention in Care (RiC) programs using standard methods recommended by the U.S. Panel on Cost-effectiveness in Health and Medicine.  Program costs from the societal perspective ranged from $47,919 to $423,913 per year or $594 to $2,753 per participant. The programs averted between 0.23-1.65 HIV infections per year.  QALYs gained ranged from 1.51-11.00.  Using a threshold of $163,889 USD, all of the programs were cost-effective and four were cost-saving. Across a range of program models, retention in care interventions were cost effective (and the majority were cost saving), suggesting that retention in care programs are a judicious use of resources.

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Oct
10
12:00 PM12:00

Steven Goodreau: Sources of racial disparities in HIV prevalence among men who have sex with men in Atlanta: A modeling study

Sources of racial disparities in HIV prevalence in men who have sex with men in Atlanta: A modeling study

Steven Goodreau, Ph.D.
University of Washington, Seattle

ABSTRACT:

Black men who have sex men (MSM) in the US have a substantially higher prevalence of infection than White MSM, and many proximal and distal explanations have been offered to account for pieces of this disparity.

We created a simulation model to assess the strength of existing hypotheses and data. We built a dynamic, stochastic, agent-based network model of Black and White MSM aged 18–39 years in Atlanta, that incorporated race-specific individual and dyadic-level prevention and risk behaviors, network attributes, and care patterns. We estimated parameters from two Atlanta-based studies in this population (n=1117), supplemented by other published work. We modeled the ability for racial assortativity to generate or sustain disparities in the prevalence of HIV infection, alone or in conjunction with scenarios of observed racial patterns in behavioral, care, and susceptibility parameters. 

Race-assortative mixing alone could not sustain a pre-existing disparity in prevalence of HIV between Black and White MSM. Differences in care cascade, stigma-related behaviors, and CCR5 genotype each contributed substantially to the disparity (explaining 10.0%, 12.7%, and 19.1% of the disparity, respectively), but nearly half (44.5%) could not be explained by the factors investigated. A scenario assessing race-specific reporting differences in risk behavior was the only one to yield a prevalence in black MSM (44.1%) similar to that observed (43.4%). Racial assortativity is an inadequate explanation for observed disparities. Work to close the gap in the care cascade by race is imperative, as are efforts to increase serodiscussion and strengthen relationships among Black MSM particularly. Further work is urgently needed to identify other sources of, and pathways for, this disparity, to integrate concomitant epidemics into models, and to understand reasons for racial differences in behavioral reporting.

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Oct
4
12:45 PM12:45

ISGMH Lecture: Current Issues in LGBTQ Health featuring Eileen Pagán - Supporting and Lifting LGBTQ+ Youth of Color Experiences

Eileen Pagán, M.A.T., is a boricua femme genderqueer art therapist and activist from the south and uses they/them pronouns. Eileen recently graduated from Adler University with a double masters degree in Art Therapy and Mental Health Counseling and began their career at Center on Halsted with the Youth Department. During their time there, they created a Clinical Youth Training Program that aims to support LGBTQ youth experiencing homelessness. Rooted in southern community organizing and social justice, Eileen recently made a giant leap to Atlanta, GA and is currently working as an Art Therapist at the National Youth Advocate Program building LGBTQ competency in the foster care system. During their down time, they organize with local grass root organization Southerners On New Ground (SONG) working towards queer and PoC liberation in the South.

This lecture will be on Wednesday, October 4th from 12:45-2:15 pm in the Stonewall Conference Room of 625 N. Michigan Suite 1400. Lunch will be served. For those who would like to attend remotely, we will be streaming this lecture remotely on BlueJeans.

To RSVP and find out more about ISGMH click here!

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Oct
3
12:00 PM12:00

Anna Satcher-Johnson & Ruiguang Song: Estimating HIV incidence, prevalence, and undiagnosed infection in the United States

Estimating HIV incidence, prevalence, and undiagnosed infection in the United States

Anna Satcher-Johnson, M.P.H. & Rick Song, Ph.D.
Centers for Disease Control and Prevention

ABSTRACT:

The burden of HIV infection and health outcomes for people living with HIV varies across the United States. New methods allow for estimating national and state-level HIV incidence, prevalence, and undiagnosed infections using surveillance data and CD4 values. 

Methods: HIV surveillance data reported to the Centers for Disease Control and Prevention and the first CD4 value after diagnosis were used to estimate the distribution of delay from infection to diagnosis based on a well-characterized CD4 depletion model. This distribution was used to estimate HIV incidence, prevalence, and undiagnosed infections during 2010–2014. Estimated annual percentage changes were calculated to assess trends. 

During 2010–2014, HIV incidence decreased 10.3% (EAPC = -3.1%) and the percentage of undiagnosed infection decreased from 17.1% to 15.0% (EAPC = -3.3%) in the United States; HIV prevalence increased 9.1% (EAPC = 2.2%). In 2014, Southern states accounted for 50% of both new HIV infections and undiagnosed infections. HIV incidence and undiagnosed infection decreased in the United States during 2010–2014; however, outcomes varied by state and region. Progress in national HIV prevention is encouraging but intensified efforts for testing and treatment are needed in the South and states with high percentages of undiagnosed infection.

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Oct
2
9:00 AM09:00

TC-CFAR Symposium: “Bridging the Disciplines to Understand HIV Transmission”

Symposium Overview

Join us for the Annual Third Coast CFAR Symposium: Bridging the Disciplines to Understand HIV Transmission. Taking a multi-disciplinary approach, the goal of the Third Coast CFAR Symposium is to integrate cellular, molecular, clinical, and behavioral perspectives into three sessions that examine HIV transmission in the context of the host, the virus, and intervention.

These sessions will include invited experts from outside Chicago as well as short talks from Third Coast CFAR investigators. Two poster sessions will showcase the breadth of HIV/AIDS research being conducted across Chicago as well as highlighting services provided by the Third Coast CFAR.

Register for Symposium

Call for Abstracts

Symposium Agenda at a Glance

Detailed schedule to be posted in September

Continental Breakfast & Poster Set-up

Session I: Focus on Host
Paul Volberding, MD, University of California San Francisco
Petronela Ancuta, PhD, University of Montreal
Maximo Brito, MD, MPH, University of Illinois-Chicago

Short talks

Poster Session I

Lunch

Session II: Focus on Virus
Ron Swanstrom, PhD, University of North Carolina
Jonathan Carlson, PhD, Microsoft

Short talks

Poster Session II

Session III: Focus on Interventions
Steven Safren, PhD, University of Miami
Adam Carrico, PhD, University of Miami

Short talks

Reception

-------------------

Administrative Contacts

Kamara Fant
kamara.fant@northwestern.edu
312-503-4641

Fern Murdoch
f-murdoch@northwestern.edu
 312-503-4624

The Third Coast CFAR Symposium Organizing Committee

Thomas Hope, PhD                                    
Cell and Molecular Biology
Northwestern University

Judith Moskowitz, PhD
Medical Social Sciences
Northwestern University

Jessica Ridgway, MD
Medicine/Infectious Diseases
University of Chicago

Symposium Information

The Annual Third Coast CFAR Symposium, Bridging the Disciplines to Understand HIV Transmission, will take place at the Prentice Women’s Hospital 3rd Floor Conference Center October 2, 2017.

Third Coast Center for AIDS Research
625 N Michigan Ave.
Suite 1400
Chicago, IL 60611

Prentice Women’s Hospital 3rd Floor Conference Center
250 E. Superior St.
Chicago, IL 60611

 

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Sep
25
12:00 PM12:00

TC-CFAR Seminar: Dr. Robert L. Murphy

Dr. Robert L. Murphy will be presenting for the TC-CFAR Seminar Series

Location: 
Northwestern University - Chicago Campus
Wieboldt Hall, Room 431
340 E. Superior Ave.

Dr. Robert L. Murphy is the Director of the Center for Global Health at Northwestern University where he holds his primary academic appointment as the John P. Phair Professor of Medicine. He also holds an appointment as Professeur Associé de Recherche at the Pierre et Marie Curie Université-Paris in France. Dr. Murphy’s primary research and clinical interest is in viral infections. His research includes drug development of new antiretroviral drugs and vaccines for HIV and viral hepatitis and the scale-up of therapy for AIDS, tuberculosis and malaria in sub-Saharan Africa.

Dr. Murphy is Special Advisor to the President’s Emergency Plan for AIDS Relief (PEPFAR) program in Nigeria, sponsored by the Harvard School of Public Health, where he has overseen the set up of 42 clinics that currently treat over 75,000 patients with HIV/AIDS. He also consults on NIH-supported antiretroviral education projects in Senegal and is Pricipal Investigator for Northwestern’s NIH/Fogarty International AIDS Training Grant based in Nigeria and Mali and the Northwestern Fogarty Frameworks grant. International activities and interests include assisting in the establishment of an AIDS Clinic in rural southern Kenya funded by the African Village Clinics Foundation of Chicago.

Dr. Murphy is the Principal Investigator for the National Institutes for Allergy and Infectious Diseases (NIAID) Adult AIDS Clinical Trials Group (ACTG) at Northwestern. Within ACTG he has held numerous leadership positions including membership on the Scientific Agenda Steering Committee and Adult Executive Committee, the governing body of the group. He is a member of multiple medical societies and sits on the boards of several non-profit organizations including the Drucker Family Charitable Trust, the International AIDS Education Project, Objectif Recherche Vaccin SIDA and the Midwest AIDS Foundation, of which he is the founder.

Professor Murphy has been with Northwestern University since 1978. After receiving his AB from Boston University, he attended the Loyola Stritch School of Medicine and later completed his internship, residency, and fellowship in infectious diseases at the McGaw Medical Center, Northwestern University. Professor Murphy has remained with Northwestern, becoming professor of medicine in 1999. He presently holds the distinguished post of John P. Phair Professor of Medicine.

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Sep
19
12:00 PM12:00

Carl Latkin: Social network approaches to HIV prevention and care

Social network approaches to HIV prevention and care

Carl Latkin, Ph.D.
Johns Hopkins Bloomberg School of Public Health

ABSTRACT:
The presentation will outline how social network approach can be utilized to reach hidden populations. Embedded in social network dynamics are social influence process that can be capitalized on to promote and sustain behavior change. The presentation will briefly provide guidance on tailoring social network inventories and then focus on developing and implementing RCT of network interventions and  measuring outcomes and controlling for contamination.

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Sep
11
12:00 PM12:00

TC-CFAR Seminar: Dr. Warner C. Greene

Warner C. Greene, MD, PhD
Director, Senior Investigator, and Nick and Sue Hellmann Distinguished Processor, Translational Medicine at Gladstone Institute of Virology and Immunology
Professor of Medicine, Microbiology and of Immunology, UCSF
Member, Institute of Medicine of the National Academies
Fellow, American Academy for the Advancement of Science
Co-Director, UCSF-GIVI Center for AIDS Research
Councilor and President, Association of American Physicians.

Presenting: Death By Friendly Fire During HIV Infection
Location: 

Northwestern University - Chicago Campus
Wieboldt Hall, Room 431
340 E. Superior Ave.

 

Dr. Greene earned a bachelor’s degree at Stanford University and an MD/PhD at Washington University School of Medicine. He took his internship and residency training in Medicine at the Massachusetts General Hospital at Harvard. After serving as a Senior Investigator at the National Cancer Institute and a Professor of Medicine and Howard Hughes Investigator at Duke University Medical Center, Dr. Greene accepted his current position as the Founding Director of the Gladstone Institute of Virology and Immunology in 1991. The ongoing research in Dr. Greene’s laboratory focuses on the molecular mechanisms underlying HIV pathogenesis, latency, and transmission. He is the author of more than 366 scientific papers and has been recognized as one of the 100 Most Cited Scientists in the world. In 2007, Dr. Greene expanded his work to include global health in sub-Saharan Africa in his service as president and executive chairman of the Accordia Global Health Foundation. Accordia established the Infectious Diseases Institute at Makerere University in Uganda, which has trained thousands of African health care workers, is caring for 30,000 HIV-infected patients, and has brought health care to nearly 500,000 people living in remote rural regions of Uganda.

 

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Sep
7
12:00 PM12:00

ISGMH Lecture: Joy Messinger at ISGMH's Current Issues in LGBTQ Health Lecture Series

When: Thursday, September 7th from 12:00-1:30 pm

Location: Stonewall Conference Room, 625 N. Michigan Suite 1400, Chicago, IL 60611

Lecture Title: “Our Survival Depends on Each Other: The Urgency of Intersectionality to Support the Health, Wellness, and Healing of LGBTQ Communities”

Click here for more lecture details and to RSVP.

If you are unable to join in person, we invite you to attend remotely using BlueJeans. Lunch will be served!

ISGMH’s Current Issues in LGBTQ Health Lecture Series focuses on highlighting important work being done in the field of LGBTQ health. Each lecture showcases the work of a different speaker or speakers. All of our lectures are open to the public to attend (as space allows) and available via livestream. Unless otherwise stated, our lectures are held in the Stonewall Conference Room at 625 N. Michigan Avenue, Suite 1400, Chicago, IL 60611.

 

 

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Jul
26
9:00 AM09:00

Conference: 1st North American Social Networks (NASN) Conference 2017

Workshop on Agent-Based Models in Social Network Analysis Using NetLogo
2 sessions, morning & afternoon: 9:00am until 4:00 pm on July 26, 2017
Attendance limited to 16 people

Instructors:
Dr. Wouter Vermeer and Gabriella Anton of Northwestern University

Session 1:
1) Introduction to ABM and Netlogo [1.5 hour]
2) Practical Assignments (part 1) [1.5 hour]
(Participants are encouraged to bring their own research questions and data)

Session 2:
1) Centralized evaluation of practical assignments (part 1) [0.5 hour]
2) Network extension [1 hour]
3) Practical Assignment 2 [1.5 hour]
(Participants are encouraged to bring their own research questions and data)

Description:
NetLogo (http://ccl.northwestern.edu/netlogo/) is a free, open source, modeling environment for simulating natural and social phenomena, authored by Prof. Wilensky, and it is currently the most cited agent-based modeling language in social sciences. NetLogo is designed to be a low threshold, high sealing programming environment that affords use among both young (or novice) coders and experts alike. Ever since its conception in 1999, the Center for Connected Learning and Computer Based Modeling (CCL) has continuously developed new language features and extensions to NetLogo. Among them is the Network-extension, which provides powerful Network Science capabilities in NetLogo.
NetLogo models, and agent-based models in general, are well suited for studying complex systems over time, and for executing scenario analyses. Modelers can give instructions to hundreds or thousands of "agents", all operating independently. This makes it possible to explore the 13 connection between the micro-level behavior of individuals and the macro level patterns that emerge from their interaction. With the addition of the Network extensions, NetLogo is particularly well suited for incorporating the networks that underlie systems in the analysis of such patterns, and for exploring the local rules that allow certain network structures to emerge. In the workshop, we provide an introduction on the use of NetLogo. We adopt a practical, hands on workshop approach, in which approximately half of the time will be spent with participants exploring and programming in NetLogo. For this workshop participants are encouraged to provide their own research questions (and/or data). We will help participants get started on their own NetLogo models, specifically focusing on the use of the Network extension. We emphasize providing support to new and current users for effectively integrating NetLogo in their research.  The workshop will consist of two 3 hours sessions. To allow for sufficient room for interactions we impose a maximum number 16 participants to each session.

Link to Conference Information: http://insna.org/nasn2017/

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Jun
29
2:00 PM14:00

Symposium: The State of LGBTQ Youth Health and Wellbeing: Strengthening Schools and Families to Build Resilience

Be sure to RSVP here: bit.ly/2qIonGX

We are excited to invite you to our second Annual Symposium entitled “The State of LGBTQ Youth Health and Wellbeing: Strengthening Schools and Families to Build Resilience.” Organized by ISGMH, the Center for Prevention Implementation MethodologyAdvocates for Youth, and the AIDS Foundation of Chicago, the symposium will be held on June 29th from 2:00-4:30 with a reception to follow. This event is supported by the Illinois Safe Schools Alliance.

This event will be live streamed. If you wish to attend this event remotely, please visit https://bluejeans.com/579239263  

Keynote SpeakerDr. David Purcell, JD, Ph.D., Deputy Director for Behavioral and Social Science, Center for Disease Control and Prevention

Panel Presenters:

Dr. Guillermo (Willy) Prado, Leonard M. Miller Professor of Public Health Sciences, Director of the Division of Prevention Science and Community Health at the Miller School of Medicine, and Dean of the Graduate School, University of Miami

Dr. Dorothy Espelage, Ph.D., Professor of Psychology, University of Florida.

Dr. Brian Mustanski, Ph.D., Director of the Institute for Sexual and Gender Minority Health and Wellbeing, Professor of Medical Social Sciences, Psychiatry and Behavioral Sciences and Weinberg College of Arts and Sciences, Northwestern University

Youth leaders from the Illinois Caucus for Adolescent Health

Remarks:

Dr. Karen Parker, Ph.D., M.S.W., Director of the Sexual & Gender Minority Research Office, National Institutes of Health

Debra Hauser, President, Advocates for Youth

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Jun
23
9:00 AM09:00

Meeting: Center for Translational and Implementation Research (CTRIS) Meeting @ National Heart, Lung, and Blood Institute (NHLBI)

Meeting Topic:
Eliminating Cardiovascular Disparities through Community Engaged Research

Methods and Milestones Session:
Session Chairs are Dr. Hendricks Brown & Dr. JD Smith of Ce-PIM

For more information about the Center for Translational Science & Implementation Research and the National Heart, Lung, and Blood Institute, click here: https://www.nhlbi.nih.gov/about/org/ctris

 

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May
23
12:00 PM12:00

Chen-Pin Wang: Assessing causal inference and disparity in the latent variable prediction framework

Assessing causal inference and disparity in the latent variable prediction framework

Chen-Pin Wang, Ph.D.
University of Texas-San Antonio

ABSTRACT:
Latent Growth Mixture Modeling (LGMM) is a useful statistical tool to characterize the heterogeneity of the longitudinal development of a prognostic variable using the so-called latent classes. Recently an advanced statistical learning methodology (Jo 2016) was developed to validate the scientific utility of the latent classes regarding the prediction of a target outcome of interest. This presentation focuses on deriving causal inference and health disparity in this prediction model framework. The proposed method involves LGMM analysis of the prognostic variable, validating the prediction of the latent classes for the distal (future) outcome of interest, and then incorporating the inverse propensity score weighting technique to deriving causal relationship between the prognostics classes with the distal outcome and the associated health disparity. I will demonstrate the proposed method using a longitudinal epidemiology study of patients with type 2 diabetes that aimed at assessing the prediction of glycemic control for cardiovascular diseases related hospitalization and the racial disparity in this relationship.

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May
16
12:00 PM12:00

Booil Jo: Statistical learning with latent prediction targets

Statistical learning with latent prediction targets

Booil Jo, Ph.D.
Stanford University

ABSTRACT:
In predictive modeling, often aided by machine learning methods, much effort is concentrated in identifying good predictors. However, the same level of rigor is often absent in improving the outcome side of models. In this study, we focus on this rather neglected aspect of model development and demonstrate the use of longitudinal information as a way of improving the outcome side of predictive models. This involves optimally characterizing individuals’ outcome status, classifying them, and validating the formulated prediction targets. None of these tasks are straightforward, which may explain why longitudinal prediction targets are not commonly used in practice despite their compelling benefits. As a practical way of improving this situation, we explore a semi-supervised learning approach based on growth mixture modeling (GMM), a method of identifying latent subpopulations that manifest heterogeneous outcome trajectories. In the proposed approach, we utilize the benefits of the conventional use of GMM for the purpose of generating potential candidate models based on empirical model fitting, which can be viewed as unsupervised learning. We then evaluate candidate GMM models on the basis of a direct measure of success; how well the trajectory types are predicted by clinically and demographically relevant baseline features, which can be viewed as supervised learning. We examine the proposed approach focusing on a particular utility of latent trajectory classes, as outcomes that can be used as valid prediction targets in clinical prognostic models. Our approach is illustrated using data from the Longitudinal Assessment of Manic Symptoms study.

Suggested readings:

Jo B, Findling RL, Wang C-P, Hastie JT & the LAMS group (2017). Targeted use of growth mixture modeling: A learning perspective. Statistics in Medicine, 36, 671-686.

Jo B, Findling RL, Hastie JT, Youngstrom EA, Wang C-P & the LAMS group (in press). Construction of longitudinal prediction targets using semi-supervised learning. Statistical Methods in Medical Research.

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May
2
12:00 PM12:00

Teppei Yamamoto: Introduction to causal mediation analysis using R

Introduction to causal mediation analysis using R

Teppei Yamamoto, Ph.D.
MIT

ABSTRACT:
Researchers often seek to study not only whether a treatment has a causal effect on an outcome but also how and why such a causal relationship comes about. Causal mediation analysis is a popular method to analyze causal mechanisms using experimental or observational data. In this webinar, we provide an overview of the theoretical framework underpinning the mediation methods and discuss assumptions that play a key role for valid inference about causal mechanisms. We also cover practical issues in using the framework for social, behavioral and medical science applications. A particular focus will be on the R package mediation and how to use it in various applied setting.

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Apr
25
12:00 PM12:00

Naihua Duan: Personalized biostatistics, small data, and N-of-1 trials

Personalized biostatistics, small data, and N-of-1 trials

Naihua Duan, Ph.D.
Columbia University

ABSTRACT:
As personalized medicine is emerging as a promising paradigm to improve clinical decision-making, to customize clinical decisions for individual patients, to accommodate the unique needs and preferences for each specific patient, there is a growing need for biostatistical methods to be developed and deployed to serve the needs for this emerging paradigm. As an example, the on-going NINR-funded PREEMPT Study, http://www.ucdmc.ucdavis.edu/chpr/preempt/, has developed a smartphone app that allows chronic pain patients and clinicians to run personalized experiments (n-of-1 trials), comparing two different pain treatments, to help patients and their clinicians to choose the most appropriate pain treatment for each individual patient. Such personalized biostatistical toolkits can be utilized by frontline clinicians and their patients to address the specific clinical questions confronted by each individual patient, to enable the specification and execution of the personalized trial protocol, to facilitate the collection of outcome and process data, to analyze and interpret the data acquired, and to produce reports to the end users to help them with evidence-based decision making. This paradigm exemplifies the potential for “Small Data” (as opposed to “Big Data”) to be deployed in clinical applications for the benefits of today’s patients as the primary aim for the evidence-based investigations. Importantly, personalized biostatistics based on Small Data provides strong incentives for end-users to participate in the evidence-based investigations, as they are targeted to benefit directly from such investigations, instead of the traditional clinical research that aims primarily to benefit future patients. There is a promising potential this merging paradigm will play an important role in the future of health and related domains, to supplement the traditional top-down model for research with a bottom-up model for quality improvement.

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